The Journal of Informed Pharmacotherapy 2002;11:151.
Reviewer: James McCormack, B.Sc. (Pharm), Pharm. D.
Reviewer's email address: email@example.com
Reviewer's profession/specialty: Associate Editor, Journal of Informed Pharmacotherapy
Solomon PR, Adams F, Silver A, Zimmer J, DeVeayx R. Ginkgo for memory enhancement - a randomised controlled trial. JAMA 2002;288:835-40. Pubmed Citation
These investigators looked to determine whether or not ginkgo improves memory in the elderly.
230 community dwelling volunteers in generally good health. Their average age was 68 (range 60-82)and 59% were female.
Patients were randomized to receive either placebo or ginkgo 40 mg orally three times daily for 6 weeks. Outcome measures consisted of 14 tests of learning and memory, attention and concentration, expressive language, and a memory questionnaire. In addition, a global evaluation by spouse, relative or friend was conducted.
The duration of follow up was 6 weeks.
None of the differences between the groups were statistically different. Of the 14 tests, seven of the point estimates favoured ginkgo and seven favoured placebo.
There was no monitoring of adverse effects.
This study suggests that ginkgo at a dose of 40 mg orally three times daily for 6 weeks does not enhance memory in otherwise healthy elderly adults. Drug-associated adverse effects with this regimen was not assessed.
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