The Journal of Informed Pharmacotherapy 2003;13:150.
Reviewer: James McCormack, B.Sc. (Pharm), Pharm. D.
Reviewer's email address: firstname.lastname@example.org
Reviewer's profession/specialty: Associate Editor, Journal of Informed Pharmacotherapy
Trivedi DP, Doll R, Khaw KT. Effect of four monthly oral vitamin D3 (cholecalciferol) supplementation on fractures and mortality in men and women living in the community: randomised double blind controlled trial. BMJ 2003;326:469 PubMed Citation
These investigators compared vitamin D to placebo in the prevention of self reported fractures. The vitamin D or placebo was mailed to the each participant every 4 months and the incidence of self reported fractures was assessed.
2686 men and women living in the general community. Their mean age was 74, 24% were men. Thirty one percent of of the men had a history of cardiovascular disease while this was present on only 18% of the women.
Patients were randomized in a blinded fashion to receive either vitamin D 100,000 IU orally every four months or placebo.
The mean duration of follow up was 5 years.
This study suggests that vitamin D at a dose of 100,000 IU orally every 4 months reduces the chance of fractures in men and women between the ages of 65-65 living in the general community regardless of bone density.
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