The Journal of Informed Pharmacotherapy 2004;14:153.
Reviewer: James McCormack, B.Sc. (Pharm), Pharm. D.
Reviewer's email address: email@example.com
Reviewer's profession/specialty: Associate Editor, Journal of Informed Pharmacotherapy
Clinical efficacy of three common treatments in acute otitis externa in primary care: randomised controlled trial. van Balen FA, Smit WM, Zuithoff NP, Verhe TJ. BMJ 2003;327:1201-5 PubMed Citation
These investigators compared acetic acid, to steroid plus acetic acid, to steroid plus antibiotics in the treatment of acute otitis externa.
213 patients with acute otitis externa. The average age of the patients was 45 years and 50% were female.
Patients were randomized in a blinded fashion to receive either acetic acid, acetic acid plus triamcinolone or dexamethasone plus neomycin/polymyxin B all given three times daily until the patient had recovered.
The study duration was 21 days.
This study suggests that eardrops containing corticosteroids plus acetic acid or corticosteroids plus antibiotics are more effective than acetic acid drops on their own in the treatment of otitis externa. There is no difference in efficacy between eardrops containing a combination of ingredients.
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