Research Abstracts

The Journal of Informed Pharmacotherapy 2004;15:408.

Microbiological Quality Control Study For The Purpose Of Extending The Use Of Transfer Sets On Automated Total Nutrient Admixture Compounding Pumps

Kenneth Chung, B.Sc.(Pharm), Greg Head, B.Sc.(Pharm)

Pharmacy Department, Providence Health Care, Vancouver, British Columbia 

Canadian Society of Hospital Pharmacists (British Columbia Branch) Residency Research Presentation Night, Vancouver, British Columbia, Canada. May 2003.


A quality control study was undertaken by the departments of pharmacy and microbiology at St. Paul’s Hospital (Vancouver, BC) to evaluate the microbiological safety of total nutrition admixtures (TNA) compounded by automated compounding pumps when the use of disposable transfer sets was extended from 1 day to 2 days. This study also evaluates the potential annual cost savings of this extended use.   


A major Canadian tertiary adult acute care teaching hospital.


Transfer sets and unused part containers of ingredients were left to sit overnight on the automated compounders after daily TNA manufacturing before a TNA sample was compounded for culturing. These TNA samples were cultured using a biphasic system consisting of a tryptic soy broth component and an agar slide component. Positive results were subcultured and isolates were identified by standard methods.


Forty samples were collected and evaluated. Four bags grew Bacillus species and one bag grew coagulase-negative staphylococci.


The potential annual cost savings of this extended use was estimated to be ~$35,000. The extended use of the disposable transfer sets cannot be instituted at the present time and should be re-examined when the cause(s) of the positive results are identified and corrected.

Copyright © 2003 by the Journal of Informed Pharmacotherapy. All rights reserved.