Research Abstracts

The Journal of Informed Pharmacotherapy 2004;15:402.

Effects of Hospital Pharmacist Intervention on Non-Steroidal Anti-inflammatory Drug Use Following Hospital Discharge (INSTEAD)

Tila Pelletier, B.Sc.(Pharm.), Peter Loewen, B.Sc.(Pharm.) Pharm.D., Kerry Wilbur, B.Sc.(Pharm.), Pharm.D.

Pharmaceutical Sciences Clinical Services Unit, Vancouver Hospital & Health Sciences Centre, Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, British Columbia, Canada

Canadian Society of Hospital Pharmacists (British Columbia Branch) Residency Research Presentation Night, Vancouver, British Columbia, Canada. May 2003.


Non-steroidal anti-inflammatory drugs (NSAIDs) cause significant, dose dependant, adverse effects.  We set out to examine the effect of a direct-to-patient hospital pharmacist intervention on NSAID use following hospital discharge.  We hypothesized that pharmacist intervention could decrease or eliminate NSAID use by patients while not decreasing their quality of life (QOL). 


A major Canadian tertiary adult acute care teaching hospital.


Randomized, placebo controlled, subject blinded trial.  Eligible hospitalized patients were screened then randomized to either the non-intervention or intervention arm.  The former was given usual care by a clinical pharmacist.  The latter received additional counseling by a pharmacist investigator; both groups were given an interview and QOL assessment as baseline and thirty days. 


Nine subjects completed the trial.  All subjects in the intervention arm (n=5) achieved abstinence from NSAID compared to 2 in the non-intervention arm (n=4).  Four vs. one subject(s) in each arm, respectively, increased their use of acetaminophen.  The NSAID related risk profile improved in all subjects in the intervention arm compared to 3 in the non-intervention arm. There was no decline in the QOL in either arm.


Subjects use of NSAID decreased and use of acetaminophen increased after a hospital pharmacist intervention without affecting quality of life. 

Copyright © 2003 by the Journal of Informed Pharmacotherapy. All rights reserved.